Sometimes, the most obvious use for a particular domain name is in a manner that would either be offensive, controversial, or negative. This will probably be common sense for most people, but it is a good idea to keep the lease to own option off for domain names that could be used in a way that could damage its future usage.
I recently sold the a two word .com domain name that was acquired by a political campaign. The domain name was first used as a forwarder to a YouTube video, but it now hosts a landing page with that video. The title of the video matches the domain name without the extension. I would classify this as a way to cast an opponent in a poor light.