Timing is everything, and that certainly applies to selling domain names. In my opinion, the time that you choose to send a sales email is critical and can be the difference between selling a domain name to a willing buyer and missing an opportunity to connect with that prospect.
In the majority of situations, I will only email a prospective buyer once. If the buyer doesn’t respond to my email, I likely will not email the person again because I don’t want to bother him or her (two exception being if the prospect replies with interest or if it is the result of an inbound inquiry). I generally assume a lack of a response indicates a lack of interest.
With that being said, if I send an email to a prospective buyer and she doesn’t respond, as a matter of practice I probably won’t send a second email to avoid being a pest. There’s a chance that the prospect had no interest in the domain name and that is why she didn’t respond, and there’s also a chance the email was received at an inopportune time. For me, chances are good that I will never find out.
For the most part, I try to send emails to prospective buyers Monday afternoon through Thursday afternoon. I believe that most business people have quite a bit of things to do on Monday mornings, and most people have either checked out by Friday afternoon or they are working hard to get things done before leaving the office. I don’t usually email people on the weekend because I try not to work, but more importantly, I would expect the email to join many other unread emails, possibly going to the bottom of a priority list. I try to email people in the early afternoon because that is the most likely time that the recipient is free. I don’t like to email people during a holiday.
One other consideration to make is the recipient’s timezone. The time the recipient receives the domain name is far more important than when I send it. I may create an email and save it in draft mode until the time I think it would be received and most likely to be read.
I am sure arguments can be made about timing. Some people might find success reaching a small business owner on the weekends. The best thing to do is to test to see what works for you.